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FOCIS 2010

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FOCIS 2010: Final Scientific Program

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Wednesday, June 23
3:00-6:00 pm Registration Open
8:00 am-5:30 pm Basic Immunology in Medicine: Update 2010 (separate registration required)
Thursday, June 24
7:00 am-5:00 pm Registration Open
8:00 am-5:00 pm FOCIS Centers of Excellence Trainee Satellite Symposium (invitation only)
8:00 am-4:15 pm Interventional Immunology Course (separate registration required)
8:30 am-4:30 pm

Noon-4:30 pm
FOCIS Member Society Symposia (included in FOCIS 2010 registration)
-Islet Autoreactivity in Human T1D: Advancing Discovery of Biomarkers of Disease Progression and Intervention
Co-organized by the Immunology of Diabetes Society & the Juvenile Diabetes Research Foundation

-Cross-talk between Innate and Adaptive Immune Cells at Mucosal Surfaces: Implications for Mucosal Diseases
Co-organized by the Society for Mucosal Immunology & the American Uveitis Society

-The Future of Genomic Research in Immunity & Medicine
Organized by the FOCIS Network of Consortia
Noon-7:00 pm Poster Session – Authors Optional
5:00-5:45 pm Keynote Address: HIV Vaccinology: What Does The Future Hold?
-Anthony Fauci, MD, NIAID/NIH
6:00-7:00 pm FOCIS Founders Symposium
-Pathophysiology of Human Autoimmune Disease, David Hafler, MD, Yale University
-Peripheral Tolerance in Autoimmunity, C. Garrison Fathman, MD, Stanford University
7:00-9:00 pm  Opening Reception with Exhibits & Poster Session with Authors Present
Friday, June 25
7:00 am-5:00 pm Poster Session – Authors Optional
8:30 am-noon FOCIS 10th Anniversary Symposium
-Anti-TNFs, Marc Feldmann, MD, Kennedy Institute of Rheumatology
-Robert A. Good Memorial, University of South Florida Memorial Lecture, Infectious Diseases: Inborn Errors of Immunity?, Jean-Laurent Casanova, MD, PhD, Rockefeller University
-10 Years of Aspiring to Achieve Immune Tolerance, Jeffrey Bluestone, PhD, University of California-San Francisco
-Mixed Hematopoietic Chimerism: Translational Studies, Megan Sykes, MD, Massachusetts General Hospital/Harvard Medical School

-Biology and Clinical Application of Tr1 Cells, Maria-Grazia Roncarolo, MD, HSR-TIGET
-Immunotherapy of Lymphoma by Checkpoint Modulation, Ronald Levy, MD, Stanford University
Noon-1:00 pm Delivering Effective Presentations
-Janet Palmer Hafler, PhD, Yale University
1:00-2:30 pm Afternoon Plenary Session: Immunotherapy
-B Cells and Type I Diabetes: A Clinical Trial with Rituximab, Mark Pescovitz, MD, Indiana University
-Antibody-targeted Cancer Immunotherapy, Louis Weiner, MD, Lombardi Comprehensive Cancer Center
-Preclinical and Clinical Trial Results of Regulatory T Cells, Bruce Blazar, MD, University of Minnesota
2:45-4:45 pm Concurrent Oral Abstract Sessions
-Treg-Development and Function
-Frontiers of Autoimmunity
-Genomic and Genetic Approaches to Dissect Disease Pathways
-Promoting Tumor Immunity
5:00-5:45 pm Keynote Address: What Do CD4 T Cells See in Type-1 Diabetes in the NOD Mouse?
-John Kappler, PhD, Howard Hughes Medical Institute
5:45-7:30 pm Exhibits & Poster Session with Authors Present
Saturday, June 26
7:00 am-5:00 pm Registration Open
7:30-8:30 am Poster Session – Authors Optional
8:30-10:00 am Plenary Session: Microbiome
-Microbiota and Maturation of Intestinal T Cell Responses, Nadine Cerf-Bensussan, MD, PhD, Universite Paris Descartes
-Mucosal Immune Development in Mice Colonized with Human Microbiota, Dennis Kasper, MD, Harvard Medical School
-The Intestinal Microbiota: A Platform for Immune System Manipulation, Justin Sonnenburg, PhD, Stanford University
10:15 am-noon Concurrent Thematic Symposia
-Therapies for Allergies: Mechanisms of Acquired Tolerance, Kari Nadeau, MD, PhD, Stanford University
-Abstract: Mite Allergen Decreases DC-SIGN Expression and Modulates Human Dendritic Cell Differentiation and Function in Allergic Asthma, Jiu-yao Wang, MD, DPhil, National Cheng Kung University
-Infection, Immunity and COPD, Karen Norris, PhD, University of Pittsburgh

-Innate Immune Responses in Asthma, Marsha Wills-Karp, PhD, Cincinnati Children's Hospital Medical Center 

-Intrinsic Defects in Human B Cell Responses, Bonnie Blomberg, PhD, University of Miami
-Abstract: Analyzing Immune Responses to the Seasonal Influenza Vaccine to Understand Immunosenescence, David Furman, PhD, Stanford University
-Molecular Defects in T Cell Activation with Age, Jorg Goronzy, MD, PhD, Emory University
-Rational Design of Influenza Vaccines for Older Adults: Beyond Antibody Responses, Janet McElhaney, MD, University of Connecticut Health Center

B Cells in Disease
-Nef-shuttling Intercellular Highways for HIV Evasion of Antibody Production, Andrea Cerutti, MD, Weill Medical College of Cornell University
-Abstract: Human T Follicular Helper Cells Comprise Subsets Specialized for Help of Distinct B Cell Subsets, Salah-Eddine Bentebibel, Baylor Institute for Immunology Research
-Selection of the B Cell Repertoire, Betty Diamond, MD, Feinstein Institute for Medical Research
-Selection of Autoreactive B Cells in Autoimmune Diseases, Eric Meffre, PhD, Yale University
1:00-2:30 pm Afternoon Plenary Session: Emerging Analytic Technologies
-Assessing the Paradoxical Relationship between the Immune System & Cancer for Clinical Diagnostics & Therapies, James Heath, PhD, California Institute of Technology
-Exploring Systems Medicine using Translational Bioinformatics, Atul Butte, MD, PhD, Stanford University School of Medicine
-Modulating Vaccine Responses with Innate Immunity, Bali Pulendran, PhD, Emory University
2:45-4:45 pm Concurrent Oral Abstract Sessions
-The Good, the Bad & the B Cell
-Immune Assessment: Biology Technology
-Discerning Tregs in Disease
-Regulating Inflammation
5:00-5:45 pm Keynote Address: Inflammatory Diseases Regulated by T-bet
-Laurie Glimcher, MD, Harvard University
5:45-7:00 pm Poster Session with Authors Present
7:00-9:00 pm  Standardization and Proficiency Testing:  Lessons, Challenges, and Future Directions - coordinated by the FOCIS Human ImmunoPhenotyping Consortium (HIP-C)
-Welcome and Overview, Jonathan Braun, MD, PhD, University of California-Los Angeles
-Cancer Immunotherapy Consortium, Sylvia Janetzki, MD, ZellNet Consulting
-Immunotoxicology Technical Committee, ILSI/HESI Representative
-BD/National Institutes of Health Collaboration, Maria Jaimes, MD
-National Institutes of Allergy & Infectious Diseases, Daniel Rotrosen, MD
-Panel Discussion, Moderated by Philip McCoy, PhD, National Heart Lung and Blood Institute and Holden Maecker, PhD, Stanford University
Panelists: Sylvia Janetzki, MD, Cancer Immunotheraphy Consortium; Deborah Phippard, PhD, Immune Tolerance Network; Thomas Denney, MSc, Center for HIV-AIDS Vaccine Immunology; Maria Jaimes, MD, BD/National Institutes of Health Collaboration; FDA Representative; Daniel Rotrosen, MD, NIAID; Michael Amos, PhD, National Institute of Standards & Tecnology; Immunotoxicology Technical Committee, ISLI/HESI Representative
Sunday, June 27
8:30-10:00 am Plenary Session: MicroRNAs
-MicroRNAs Control in Lymphocytes, Klaus Rajewsky, MD, Harvard Medical School
-MicroRNAs Involved in B Cell Development and Malignancy, Ricardo Dalla-Favera, MD, Columbia University
-Negative Regulation of Innate Immunity by MicroRNAs, Luke O'Neill, PhD, Trinity College Dublin
10:15 am-noon Concurrent Thematic Symposia
Immune Reconstitution
-Functional T Cell Reconstitution Following Immune Ablation and Autologous Hematopoietic Stem Cell Transplantation in Multiple Sclerosis, Amit Bar-Or, MD, Montreal Neurological Institute, McGill University
-Abstract: Donor Tr1 Cells Potently Expand in vivo and Prevent GVHD after TLI/ATS Non-myeloablative Conditioning and Allogeneic Bone Marrow Transplantation, Asha Pillai, St. Jude Children's Research Hospital
-Lymphopenia and Adoptive Immunotherapy: Friend or Foe?, Crystal Mackall, MD, NIH/NCI

-Human Thymic Epithelial Cell (Tec) in vitro and in vivo Systems for the Promotion of T Lymphopoiesis from Cord Blood Hematopoietic Stem Cells (Cb-Hsc), Phong Le, PhD, Loyola University Chicago

-Role of Autophagy in Cancer and Therapy, Eileen White, PhD, Rutgers University
-Nod Proteins in Infection Inflammation and Disease, Dana Philpott, PhD, University of Toronto
-T Cell Intrinsic Roles for Autophagy in Adaptive Immunity, Craig Walsh, PhD, University of California

-Autophagy in Antiviral Immunity, Akiro Iwasaki, PhD, Yale University School of Medicine

-Sensing Cytoplasmic Danger Signals by the Inflammatome, Emad Alnemri, PhD,  Thomas Jefferson University
-Abstract: Genome-wide Innate Immune Responsiveness Profiles of Patients with Inborn Errors of Toll-like Receptor Signaling, Laia Alsina, Baylor Institute for Immunology Research

-Title TBA, Speaker TBA
-The Inflammasome in Health and Disease, James Verbsky, MD, PhD, Medical College of Wisconsin
1:00-2:30 pm Afternoon Plenary Session: Host Pathogen Interface
-Immune Regulation at Mucosal Sites, David Artis, PhD, University of Pennsylvania
-HIV/SIV Vaccine Efficacy Dependent on the Dose of SIVmac251 Challenge Exposure in Macaques, Genoveffa Franchini, MD, National Cancer Institute
-Immune Recognition of the Fungal Cell Wall: The Taste of a Fungus, Neil Gow, PhD, University of Aberdeen
2:45-4:45 pm Concurrent Oral Abstract Sessions
-Cytokine Influence on Immunity
-Novel Therapeutic Approaches
-Response to Pathogens
-Orchestrating Immune Responses
5:00-5:45 pm Keynote Address: Immunogenetics of HIV Infection
-Bruce Walker, MD, Ragon Institute of MGH, MIT and Harvard