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Tuesday, June 21


8:00 am - 5:00 pm Basic Immunology in Medicine: Update 2016  
8:00 am - 5:00 pm Computational Immunology Course  

Wednesday, June 22


8:00 am - 5:00 pm Clinical Trials


Member Society Symposia (half days)


8:00 am - 12:00 pm

Eating into Transplantation Tolerance - American Society for Histocompatibility and Immunogenetics with The Transplantation Society

Chairs: Shane T. Grey, PhD; Elaine F. Reed, PhD; Stefan Tullius, MD, PhD; Megan Sykes, MD

8:00-8:10am Introduction

8:15-8:45am Complement: An Expected Force From "Within" - Claudia Kemper, PhD 

8:45-9:15am Targeting Metabolism as a Means of Regulating Immune Responses - Jonathan Powell, MD 

9:15-9:45am Early Experiences in Clinical Treg Cell Therapy in Transplantation - Qhizi Tang, PhD 

30 minute coffee break

10:15-10:45am Role of Blood Vessels in Alloreactivity and Exacerbation of Rejection by Hyperlipidemia - Jordan Pober, MD, PhD

10:45-11:15am Hyperlipidemia in Tolerance and Rejection - John Iacomini, PhD

11:15-11:45am Harnessing the Powers of Regulatory T cells in Transplantation - Megan Levings, PhD


8:00 am - 12:00 pm

Adult and Pediatric Immune Deficiency and Risk of Malignancy - American Academy of Allergy, Asthma, and Immunology with the American College of Allergy, Asthma, and Immunology

Chair: Marianne Frieri MD, PhD, FACAAI, FAAAAI


8:00-12:00pm Adult and Pediatric Immune Deficiency and Risk of MalignancyMarianne Frieri MD, PhD, FACAAI, FAAAAI


8:00 am - 12:00 pm

Immunophenotyping to Understand Mechanisms in Human Disease - Canadian Society for Immunology

Chairs: Ciriaco A. Piccirillo, PhD; Tania Watts, PhD


8:30-8:35am Introduction - Tania Watts, PhD

8:35-9:10am Precision Medicine in Kawasaki Disease – Learning from Biology to Improve Outcomes - Rae Yeung, MD, PhD, FRCPC

9:10-9:45am The Role of TRAF1 in Regulating Inflammation - Ali Abdul Sater, PhD

9:45-10:20am Molecular and Functional Dissection of Inheritable Mutations in the Human FOXP3 Gene: Implications for Therapy.” Ciriaco Piccirillo, PhD

15 minute coffee break

10:40-11:15am Biomarker Discovery Using Phospho-flow and Mass Cytometry - Cindy Guidos, PhD

11:15-11:50am Allodepleted T cells to Promote Immune Reconstitution After Haplo-identical Stem Cell Transplantation - Denis-Claude Roy, MD, FRCPC

11:50-noon Closing remarks - Ciriaco Piccirillo, PhD



12:00 pm - 2:00 pm

 FCE Fusion: Careers. Collaboration. Connection.

Learn more here


12:00 pm - 12:45 pm

Women In Transplantation Lunch


Member Society Symposia (half day)


12:45 pm - 4:45 pm

The Role of the Microbiome in Inflammatory Eye Disease - American Uveitis Society


Chairs: Kathryn Pepple, MD, PhD; Phoebe Lin, MD, PhD



12:45-12:50pm Introduction - Kathryn Pepple, MD, PhD

12:50-1:00pm The Microbiome in Immunity Overview - Phoebe Lin, MD, PhD

1:00-1:25pm Commensal Microbiota as a Potential Trigger of Uveitis - Rachel Caspi, PhD

1:25-1:50pm The Gut Microbiome in Uveitis - Phoebe Lin, MD, PhD

1:50-2:15pm The Oral Microbiome and Glaucoma - John Danias, MD

2:15-2:45pm Coffee break

2:45-3:10pm The Local Ocular Microbiome: Overview and Infectious Keratits - Michael Zegan, MD

3:10-3:35pm The Local Microbiome in Dry Eye and Viral Conjunctivitis - Cecilia Lee, MD

3:35-4:00pm Bioinformatics and Big Data Approaches in Microbiome Studies - Aaron Lee, MD MSCI

4:00-4:25pm Panel Discussion - Moderators: Kathryn Pepple, MD, PhD; Phoebe Lin, MD, PhD

12:45 pm - 4:45 pm

Immune Tolerance Strategies in Multiple Sclerosis - British Society for Immunology with the Immune Tolerance Network 


Chairs: Sandra Amor, Bsc, PhD; David Hafler, MD; Jerry Nepom, MD PhD



12:45–12:55pm Introduction - Sandra Amor, Bsc, PhD; David Hafler, MD

12.55–1:30pm MS drugs may shed insight in to how to control antigen-specific autoimmunity - David Baker, PhD

1:30–2:05pm Single cell genomics identifies novel regulators of tissue inflammation - Vijay Kuchroo, DVM, PhD

2:05–2:40pm Generation of inflammatory Th1-Tregs in multiple sclerosis - Margarita Dominguez-Villar, PhD

15 minute coffee break

2:55–3:30pm Switching off unwanted immune responses: the mechanism of antigen-specific immunotherapy with T cell epitopes - David Wraith, PhD

3:30–4.05pm Multiple sclerosis transcriptome analysis - 
Eoin McKinney, PhD

4:05–4:40pm Reconstitution of immune cell populations in multiple sclerosis patients after autologous stem cell transplantation (ITN HALT-MS trial) - Fred Karnell, PhD

4:40–4:45pm Final discussion - Jerry Nepom, MD, PhD; Sandra Amor, Bsc, PhD

12:45 pm - 4:45 pm

Mechanisms that Drive Human Autoimmune Disease and Implications for PreventionCooperative Study Group for Autoimmune Disease Prevention (CSGADP) with NIH, NIAID, NIDDK 

Chairs: Jane Buckner, MD; Thomas Esch, PhD


12:45-1:00pm Introduction to the CSGADP - Thomas Esch, PhD

1:00-1:30pm Tracking the Adaptive Immune Response in RA - Jane Buckner, MD

1:30-2:00pm Context Matters- Matrix and the Immune response - Paul Bollyky, PhD

2:00-2:30pm Looking into the Tissues in T1D - Matthias von Herrath, MD

15 minute coffee break

2:45-3:15pm MAIT Cells in Pathogenesis and Prediction of T1D - Nora Sarvetnick, PhD

3:15-3:45pm Genetic and Epigenetic Factors that Drive Autoimmunity - David Hafler, MD

3:45-4:30pm Early Events in the Transition to Systemic Lupus Erythematosus - Judith James, MD, PhD

12:45 pm - 4:45 pm

Inflammation or Resolution: Decision Making at Mucosal Surfaces - Society for Mucosal Immunology

Chairs: Anuradha Ray, PhD; Nicholas Lukacs, PhD


12:45-1:25pm Immune Tolerance in the Respiratory Tract and Loss In Severe Asthma - Anuradha Ray, PhD

1:25-2:05pm Role of Extracellular Histamine Releasing Factor in Allergies and Asthma - Toshiaki Kawakami, PhD

2:05-2:45pm Microbiome, Immunity and Development of Airway Disease - Nicholas Lukacs, PhD

2:45-3:25pm Metabolism of T cells at the Interface of Immunity and Suppression - Jeffrey Rathmell, PhD

3:25-4:05pm Tissue adaptation: implications for gut immunity and tolerance - Daniel Mucida, PhD

4:05-4:45pm Specialized Pro-Resolving Mediators for the Resolution of Lung Inflammation and Infection - Bruce Levy, MD 

12:45 pm - 4:45 pm

Biomarker Discovery and Signature Profiles: New Opportunities to Assess Transplantation, Autoimmune Diseases and Cancer - Association of Medical Laboratory Immunologists with the American Society for Histocompatibility and Immunogenetics

Chairs: Elaine Reed, PhD; Barbara Detrick, PhD

12:45-12:55pm Introduction - Barbara Detrick, PhD

12:55-1:40pm Predictive and Prognostic Biomarkers in Cancer Immunotherapy - Lisa H. Butterfield, PhD

1:40- 2:25pm Identification of New Biomarkers in Systemic Sclerosis that Tract Progression of Disease - Robert Lafyatis, MD

2:25-3:10pm Donor-specific Alloantibodies in Liver Transplantation: How Should We Define and Improve Long-term Success? - Jacqueline G. O‘Leary, MD

3:10-3:55pm Type 1 IFN Signature as a Biomarker of Clinical Response to Therapy in RA - Timothy Niewold, MD

3:55-4:40pm Biomarkers of Tolerance in Renal Transplantation - Lawrence Turka, MD


5:30 pm - 6:15 pm

Opening Keynote Address

Robert Langer, PhD, Massachusetts Institute of Technology


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6:15 pm - 8:15 pm

Opening Reception

Exhibits and Poster Session (authors present)



Thursday, June 23


8:00 am - 9:30 am

Adipose as an Immune Organ

Innate Mechanisms of Thermogenesis - Ajay Chawla, MD, PhD, University of California, San Francisco
Treg Control of Metabolic Indices
- Diane Mathis, PhD, Harvard University
Role for Macrophages in Adipose Tissue Iron Homeostasis - Alyssa Hasty, PhD, Vanderbilt University

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10:00 am - 11:30 am

Type 2 Allergic Inflammation

Regulation of Type-2 Inflammation - Steve Ziegler, PhD, Benaroya Research Institute
Regulatory T Cells in Allergic Inflammation - Talal Chatila, MD, PhD, Boston Children's Hospital
Profiling Food Allergen - Specific Immune Response in Pediatric Cohorts - Cecelia Berin, PhD, Mount Sinai Hospital

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11:30 AM - 1:00 PM

“Time to GoInVivo™, validated checkpoint functional antibodies for cancer research.” - Miguel Tam, Ph.D.  - Harborview II


11:30 AM - 1:00 PM

Lupus Insight Prize Luncheon - Cityview 1
Organized by the Alliance for Lupus Research, Lupus Foundation of America, and the Lupus Research
What Can We Learn From Murine Cutaneous Lupus? - Ann Marshak-Rothstein, PhD, University of Massachusetts Medical School



1:00 pm - 2:45 pm

Type 2 Inflammation: Impact on Translation

Innate Type 2 Receptor Expressions on Airway Allergen-Specific CD4+T Cells Distinguishes Allergic Asthmatics from Allergic Non-Asthmatics - Andy Luster, MD, PhD, Massachusetts General Hospital
Function of the Human Skin Microbiome in Atopic Dermatitis - Richard Gallo, MD, PhD, University of California, San Diego
Peptide Immunotherapy for the Treatment of Allergic Disease - Mark Larche, PhD, McMaster University

Perspectives on Translation through Industry-sponsored Research: Stephen Dilly, MBBS, PhD, Aimmune, Elliot Barnathan, MD, Johnson & Johnson, Neil Graham, MBBS, MD, PhD, Regeneron

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1:00 pm - 2:45 pm

Immunologic Crossroads in Transplantation
Transplantation Tolerance: An Optimal and Feasible Solution - Megan Sykes, MD, Columbia University
Advances in Long-Term Immunosuppression: Can Improved Transplant Survival Times and Improved Quality of Life after Transplantation be Achieved? - Randy Morris, MD, Stanford University
Xenotransplantation - The Biological Answer to Regenerative Medicine - Philip O'Connell, MD, PhD, University of Sydney
- Harald Ott, MD, Massachusetts General Hospital

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1:00 pm - 2:45 pm

MircoFlora and Virome Stories
An Integrative View of Microbiome-host Interactions in Immune Disease - Ramnik Xavier, MD, PhD, Massachusetts General Hospital

The Gut Microbiota in Health and Colon Cancer - Wendy Garrett, MD, PhD, Harvard School of Public Health
Probing the Medical Microbiome - George Weinstock, PhD, The Jackson Laboratory

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3:15 pm - 5:15 pm

Oral Abstraction Session - Road Maps of Molecular Dissection of Antigen Recognition and Function


3:15 pm - 5:15 pm

Oral Abstract Session - Turbulance of Pathophysiology of Systemic Autoimmunity


3:15 pm - 5:15 pm

Oral Abstract Session - New Cells...New Frontiers


3:15 pm - 5:15 pm

Principles of Flow Cytometry for Immune Monitoring

High-sensitivity Immunoassay Platforms - Phil McCoy, PhD, NHLBI, NIH

Single-cell TCRseq Assays - Holden Maecker, PhD - Stanford University


5:30 pm - 6:15 pm

Keynote Address

Short-Lived Myeloid Cell Lifespan is Regulated by a Long Non-Coding RNA - Richard Flavell, PhD, FRS, Yale University

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 6:15 pm - 7:30 pm Exhibits and Poster Session (authors present)  
7:30 pm - 8:30 pm FOCIS Member Reception (members only)  

Friday, June 24


8:00 am - 9:30 am

Cancer Immunotherapy and Escape

Stan Riddell, MD, Fred Hutchinson Cancer Research Center
The Mechanistic Basis of Cancer Immunotherapy - Ira Mellman, PhD, Genentech
Understanding Mechanisms of Resistance to Cancer Immunotherapy - Tom Gajewski, MD, PhD, University of Chicago

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10:00 am - 11:30 am

Epigenetics: Where Environment Meets the Genome

Epigenetics in Autoimmunity: The Cross Roads of Environment and Genetics - Gary Firestein, MD, University of California, San Diego
Tim Spector, MD, MSc, FRCP, King's College London

Enhancers Delineate Disease-Associated Regulatory Nodes in T Cells - Golnaz Vahedi, PhD, University of Pennsylvania

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11:30 am - 1:00 pm

Where Academia Meets Biotech: Partnering with Venture Capital and Biotech Companies
Chair: Larry Turka, MD, Harvard Medical School

Featuring Representatives from: Intellia Therapeutics, Atlas Ventures, Third Rock Ventures, Surface Oncology and Harvard Medical School

11:45 am - 1:00 pm

Meet the Science Editor Session 

11:45 am - 1:00 pm

Preparation & Review of your NIH Grant Application
Thomas Esch, PhD, NIAID

Andrea Wurster, PhD, NIAID

1:00 pm - 2:45 pm

Tissue Resident Memory Cells and Refractoriness

Resident Memory T Cells in Human Skin Disease - Rachael Clark, MD, PhD, Brigham & Women's Hospital

Resident Memory CD8T Cells: Form, Function, and Distribution - David Masopust, PhD, University of Minnesota
Tissue-Resident Natural Killer Cells - Wayne Yokoyama, MD, Washington University

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1:00 pm - 2:45 pm

Cancer and Autoimmunity: Manipulating Signal 2 for Immune Therapy and Toxicities

Targeting Immune Regulation at the Tumour Site - Sergio Quezada, PhD, University College London
Autoantibodies in Scleroderma: Markers of Cancer Immunoediting - Tony Rosen, MD, John's Hopkins University
Predicting and explaining long-term outcome in autoimmune and inflammatory disease Ken Smith, MD, PhD, University of Cambridge

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1:00 pm - 2:45 pm

Latest in the Pipeline (Industry Session)

Mucosal Immunity and IBD: Misadventures in Drug Development - Scott Plevy, MD, Janssen R&D
GSK's Pipeline: Towards Remission of Immune-Mediate Inflammatory Diseases - Paul Peter Tak, MD, PhD, GSK
Personalized Health Care in Autoimmune and Inflammatory Diseases - Andy Chan, MD, PhD, Genentech

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3:15 pm - 5:15 pm

Oral Abstract Session - Cleared for Takeoff with Innate Immunity and Innate Cells


3:15 pm - 5:15 pm

Oral Abstract Session - Regulation of Immune Function: A Passport to Health and Disease


3:15 pm - 5:15 pm

Oral Abstract Session - Destination Tolerance Restoration in Autoimmunity and Transplant


3:15 pm - 5:15 pm

Principles of Flow Cytometry for Immune Monitoring

CLIA in the FLow Cytometry Lab - Patrick Sluss, PhD, Massachusetts General Hospital
ISO: Impact on Clinical Laboratories - Jeannine Holden, MD, MBA, Beckman Coulter, Inc.
GLP: Good Laboratory Practice in Clinical Settings - Enrique Rabellino, MD, Beckman Coulter, Inc.


5:30 pm - 6:15 pm

Keynote Address

Metabolic Regulation of T Cell Function and Fate - Erika Pearce, PhD, Max Planck Institute

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 6:15 pm - 7:30 pm Exhibits and Poster Session (authors present)  

Saturday, June 25


 8:00 am - 9:30 am

Next-Gen Genetics
Beyond GWAS: Dissecting the Molecular Pathways that Lead to MS -
Phil De Jager, MD, PhD, Brigham & Women's Hospital
Fine-Mapping Autoimmune Disease Loci to Casual Variants
- Soumya Raychaudhuri, MD, PhD, Broad Institute

Epigenome Analysis from Limited Numbers of Blood Cells Reveals Principles of Differentiation - Peter van Galen, PhD, Massachusetts General Hospital

10:00 am - 11:30 am

Systems Biology and Computational Immunology

- Peter Linsley, PhD, Benaroya Research Institute
Translating a Trillion Points of Data into Therapies, Diagnostics, and New Insights into Immunological Disease - Atul Butte, MD, PhD, University of California, San Francisco
Chris Cotsapas, PhD, Yale University

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1:00 pm - 2:45 pm


Neo-Antigens Formed by Peptide Fusion in Type-1 Diabetes - John Kappler, PhD, National Jewish Medical Research Center
- Jeff Hammerbacher, Mount Sinai Hospital
Protein Modifications that Alter the Course of Human Autoimmune Disease - Mark Mamula, PhD, Yale University

Submit Comments

1:00 pm - 2:45 pm

Immune Deficiency: New Diagnostic Approaches and Immune Responses

Steve Holland, MD, National Institute of Allergy & Infectious Diseases

Inborn Errors of IL-17 Mediated Immunity in Humans - Juan Li, PhD, Rockefeller University

Immunedeficiency Diseases Due to T Regulatory Cell Dysfunction - Maria Grazia Roncarolo, MD, Stanford University

1:00 pm – 2:45 pm


New Gene-Based Vaccines Technologies: Will they Result in a Universal Flu or HIV Vaccine or Therapies for Cancer or Auto-Immune Diseases? - Margaret Liu, MD, ProTherImmune
Associated Antigens with Immunotherapeutic Potential - Victor Engelhard, PhD, University of Virginia
Universal Influenza Virus Vaccines Based on Chimeric Hemagglutinins - Adolfo Garcia-Sastre, PhD, Mount Sinai Hospital


Perspectives on Translation through Industry-sponsored Research 

Ann Marshak-Rothstein, PhD, University of Massachusetts Medical School