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Human ImmunoPhenotyping Consortium (HIP-C)

Chairs: Holden Maecker, PhD, Stanford University and J. Philip McCoy, PhD, National Heart, Lung and Blood Institute/NIH

Flow Cytometry for Immune Monitoring was organized at FOCIS 2011 and was presented on June 21 and 22 at FOCIS 2012 in Vancouver, BC.

The FOCIS Human ImmunoPhenotyping Consortium (HIP-C) is the latest in a progression of FOCIS-sponsored consortia.  Preceded by the Network of Consortia (NOC), which facilitated sharing of genome-wide association data, HIP-C was created with the goal of standardizing and sharing human immunophenotyping data.

A meeting of many of the HIP-C stakeholders was led by Bob Nussenblatt, MD at the NIH in January 2011 (FITMaN). This meeting produced a set of consensus 8-color flow cytometry panels for basic immunophenotyping of B, T, and NK cells, monocytes, and dendritic cells.  These panels are now being tested using preconfigured lyophilized reagent plates, and will be used in planned projects of the NIH Human Immunology Project Consortium, and the FOCIS Centers of Excellence.  Additional publications, and further standardized panels, are also being planned.

HIP-C was first organized at FOCIS 2009, where a roundtable discussion involving thought leaders from academia and industry was held.  This discussion provided the framework for publication of a commentary article, "A model for harmonizing flow cytometry in clinical trials" (Nat Immunol 11:975-978, 2010) and follow-up workshops at FOCIS 2010 and 2011.

For more information please contact This email address is being protected from spambots. You need JavaScript enabled to view it. , FOCIS Associate Executive Director.