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Editorial Board:Abul K. Abbas, MD, University of California, San Francisco | Carla J. Greenbaum, MD, Benaroya Research Institute Andrew H. Lichtman, MD, PhD, Brigham & Women’s Hospital | Holden T. Maecker, PhD, Stanford University |
Highlights from Recent Literature |
| Edited by Andrew H. Lichtman, MD, PhD, Brigham & Women’s Hospital, Harvard Medical School |
Anti-CD40 Antibodies that are Agonists at Both Ends
A review of Li, F and Ravetch, JV. Inhibitory Fc Receptor Engagement Drives Adjuvant and Anti-Tumor Activities of Agonistic CD40 Antibodies. Science 333; 1030-34, 2011. Reviewed by Christopher Borges and Laurence Turka, MD, Beth Israel Deaconess Medical Center and Harvard Medical School |
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Do Mast Cells Promote Tolerance to Grafts?
A review of De Vries VC, et al. Mast Cells Condition Dendritic Cells to Mediate Allograft Tolerance. Immunity 35; 550-561. Reviewed by Christopher Borges and Laurence Turka, MD, Beth Israel Deaconess Medical Center and Harvard Medical School |
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A Tumor Tyrosine Kinase Inhibitor Does More than it was Designed For
A review of Balachandran , V, et al. Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido. Nature Medicine 17,1094–1100 (2011). Reviewed by Girija Goyal and Glenn Dranoff, MD, PhD, Dana-Farber Cancer Institute, Brigham and Women’s Hospital and Harvard Medical School |
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Lacking IDO, Some Tumors Find Other Ways to Suppress Immunity
A review of Opitz, C, et al. An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor. Nature 478, 197–203 (13 October 2011) Reviewed by Girija Goyal and Glenn Dranoff, MD, PhD, Dana-Farber Cancer Institute, Brigham and Women’s Hospital and Harvard Medical School |
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Another Reason to Eat your Veggies
A review of Li, Y., et al. Exogenous Stimuli Maintain Intraepithelial Lymphocytes via Aryl Hydrocarbon Receptor Activation. Cell 147 (3): 629-640, 2011. Reviewed by Rachael A. Clark, MD, PhD, Department of Dermatology, Brigham and Women’s Hospital |
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PD1 Signaling Converts Human Th1 Cells into Tolerogenic Regulatory T Cells
A review of Amarnath, S., et al. The PDL1-PD1 Axis Converts Human TH1 Cells into Regulatory T Cells. Science Translational Medicine 3(111) 111ra120, 2011. Reviewed by Rachael A. Clark, MD, PhD, Department of Dermatology, Brigham and Women’s Hospital |
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Predicting Prognosis in Inflammatory Bowel Disease: CD8+ T Cells Hold the Key
A review of Lee, J.C. et al. Gene expression profiling of CD8+ T cells predicts prognosis in patients with Crohn disease and ulcerative colitis. J. Clin. Invest. 121: 4170-4179, 2011. Reviewed by Michelle L. Hermiston, MD, PhD, University of California San Francisco |
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Understanding Adult Hyperinflammatory Conditions: Potential Role of Hypomorphic Mutations That Compromise Cytolytic Granule Release
A review of Zhang K, et al. Hypomorphic mutations in PRF1, MUNC13-4, and STXBP2 are associated with adult-onset familial HLH. Blood 118: 5794-98, 2011. Reviewed by Michelle L. Hermiston, MD, PhD, University of California San Francisco |
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| Human Immunophenotyping Update |
Multiplex Bead Array Analysis (Luminex) for Cytokine Detection
J. Philip McCoy, PhD, National Heart, Lung and Blood Institute |
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