FOCIS Board of Directors

FOCIS President
Jonathan Braun
FOCIS Vice President
Abul K. Abbas
FOCIS Secretary/Treasurer
Jane Salmon
Past President
Gerald T. Nepom

Jacques Banchereau
Lynn Gordon
Andrew Lichtman
Holden Maecker
Phil McCoy
Stefan Meuer
Frank Nestle Robert Nussenblatt
Elaine Reed
Stephen Rich

Compliance Officer
George Tsokos

Steering Committee
Jack P. Antel
Richard S. Blumberg
Robert Colbert
Barbara Detrick
Robert Fairchild
Bernard A. Fox
Bryon Johnson
Vijay Kuchroo
Thomas MacDonald
Stefan Meuer
Gerald T. Neprom
Robert B. Nussenblatt
Elaine Reed
Bart Roep
Lanny J. Rosenwasser
Daniel Rotrosen
Brad Rovin
John E. Sims
Kendall A. Smith
Kazuo Sugamura
Megan Sykes
Matthais von Herrath

Executive Director
Gail Bast

FOCIS Update is published four times a year by the Federation of Clinical Immunology Societies. All editorial communications should be directed to:
Letter from the FOCIS 2011 President

Jonathan Braun Dear Colleagues,

I am particularly excited to share with you this year's FOCIS annual meeting. Human immunology is a vibrant field, and continues to astonish and exhaust us. This is due not only to new science, but also to the powerful technologies and clinical applications that accompany them. In response to requests from both our academic and industry constituents, we have instituted a set of new FOCIS workshops. Principles of Flow Cytometry for Immune Monitoring organized by Holden Maecker (Stanford) and Phil McCoy (NHLRSI), is a two-session how-to workshop on best practices and state-of-art in critical immune assessment technology. Clinical Trials for Immunologic Disease, organized by Robert Nussenblatt (NIH) and Carla Greenbaum (Benaroya Institute), is a one-day course on methods and resources in both autoimmune and chronic inflammatory disease clinical innovation. These join our popular, over-subscribed courses, Basic Immunology in Medicine (led by Abul Abbas and Andrew Lichtman), and Interventional Immunology (led by Scott Plevy). After all this skill-building, carry on the discussions and networking at FOCIS Lounge, a social gathering spot at the meeting located near the registration area.

Many of you reading the newsletter are to blame for all the basic and translational tumult, and FOCIS is proud to have many of you speaking in our plenaries. However, to highlight new talent and discoveries of the blameful, we invite your abstracts, the best of which will be selected and featured as talks at FOCIS 2011. The scientific sessions are, as usual, awesome: translational immunology in infectious disease, advances in vaccine strategies, modeling disease in humanized mice, cancer immunology and immunotherapy, pathogenic roles of antibodies and T cell plasticity in disease, to name just a few. Thursday features concurrent sessions of member societies, including the American Society for Histocompatibility and Immunogenetics (ASHI), the Association of Medical Laboratory Immunologists (AMLI), the American Society of Transplantation (AST), the American College of Rheumatology (ACR), the Immunology of Diabetes Society (IDS), the Juvenile Diabetes Research Foundation (JDRF), the Americas Committee for Treatment and Research in Multiple Sclerosis (ACTRIMS), the International Society for Neuroimmunology (ISNI), the ILSI Health and Environmental Sciences Institute, the Immunotoxicology Technical Committee, the Association for Cancer Immunotherapy (CIMT) and the Cancer Immunotherapy Consortium of the Cancer Research Institute. Also featured on Thursday are the Henry Kunkel Society Annual Meeting and the International Union of Immunological Societies Council Meeting.

So, if you want how-to courses on immune assessment clinical trials or translational immunology, come to FOCIS. If you want an update on basic or interventional immunology, see you in June. And, if you want to see or share your best human immunology research, join us in Washington.

Kind regards,

Jonathan Braun, MD, PhD
FOCIS President

FOCIS 2011

FOCIS 2011: A Truly Collaborative Forum
FOCIS continues to be the hub of the immunologic community with 13 different immunologic partners hosting meetings during this year's event. FOCIS 2011 focuses on accelerating the advancement of immunology through its intensive four-day schedule of presentations on the latest research, educational programming and networking opportunities. Plan now to join your colleagues in the collaborative forum that is FOCIS 2011. View the Program at a Glance.

Meeting Location:
Marriott Wardman Park
2600 Woodley Road, NW
Washington, D.C. 20008
Mark Your Calendar — Important Dates & Deadlines
Meeting registration deadline for abstract presenters March 21, 2011
Headquarter hotel registration discount deadline May 4, 2011
Meeting registration deadline May 24, 2011
FOCIS 2011 June 23-26, 2011

Attention Abstract Submitters:
If you submitted an abstract to FOCIS, notification of presentation status will be sent on March 4th. Those chosen for presentation have until March 21st to register for FOCIS 2011 or their abstracts may be withdrawn.

For a Limited Time, Save 30-40% on FOCIS Registration
There are two ways to receive a discount on FOCIS 2011 registration:
1. Book a room at the Marriott Wardman Park, FOCIS 2011 headquarter hotel, by May 4 and receive a $50 discount on your meeting registration.
2. Register before May 31 to qualify for advanced registration rates.

Congratulations Hans Doom!
FOCIS congratulates Hans Doom, PhD, Assistant Adjunct Professor at the University of California, San Francisco as the winner of complimentary FOCIS 2011 registration. Hans completed an annual meeting survey, qualifying him for the award.

Affiliated Societies Hosting Meetings during FOCIS 2011
International Union of Immunological Societies Council Meeting*
Henry Kunkel Society Annual Meeting*
*Please note that these meetings are by invitation or separate registration

FOCIS Member Societies Hosting Symposia on Thursday, June 23 (open to all delegates)
American College of Rheumatology
American Society for Histocompatibility and Immunogenetics
American Society of Transplantation
Americas Committee for Treatment and Research in Multiple Sclerosis
Association for Cancer Immunotherapy
Association of Medical Laboratory Immunologists
Cancer Immunotherapy Consortium of the Cancer Research Institute
Immunology of Diabetes Society
International Life Sciences Institute Health and Environmental Sciences Institute
International Society for Neuroimmunology
Juvenile Diabetes Research Foundation International
See more information on Member Society symposia here.

Immune Monitoring Makes an Appearance at FOCIS 2011
On the heels of the successful FOCIS Network of Consortia (NOC), created by David Hafler, MD and Stephen Rich, PhD, which united immune-mediated disease-specific consortia to share genome-wide association data, overlay results, identify commonalties between diseases and tackle the subject of genotype to phenotype, the FOCIS Human ImmunoPhenotyping Consortium (HIP-C) was born. This group, formalized at FOCIS 2009 developed out of the shared desire to standardize immunophenotyping.

Chaired by Holden Maecker, MD and Philip McCoy, PhD, HIP-C is also introducing educational programming at FOCIS 2011. The Principles of Flow Cytometry for Immune Monitoring Course is designed to teach current best practices for obtaining high-quality, reproducible flow cytometry data for immunephenotyping. The course focuses on all aspects from experimental design to sample collection and processing, data analysis and reporting. It is designed for anyone using flow cytometry for immunephenotyping, particularly in longitudinal or multi-site studies where standardization is essential.

The course agenda is available online now. FOCIS 2011 registration includes the course which will be held Friday, June 24 and Saturday, June 25 from 3:00-5:00 pm at the Marriott Wardman Park, Washington, D.C.


Clinical Trials for Immunologic Disease
Wednesday, June 22, 2011, Marriott Wardman Park, Washington, DC

Course Description:
Clinical Trials for Immunologic Disease is a basic course in clinical trial methodology, particularly as it relates to immunologic disease and designed for junior attending physicians, company project managers and PhD scientists who wish to enter into translational research. The course reviews key elements of clinical trials, including types of trials, designing feasible trials, statistical issues and surrogate markers that might be used. It will discuss strategies for entering into the funding stream. A practicum will be offered to participants using a model scenario in order to work through the issues one faces in developing a clinical trial.

Learning Objectives:
At the conclusion of this course, attendees will be able to:

Course Directors:
Carla J. Greenbaum, MD
Carla J. Greenbaum, MD
Benaroya Research Institute
Robert Nussenblatt, MD
Robert Nussenblatt, MD
National Institutes of Health
View agenda.

$150: Course rate
$250: Package rate with Interventional Immunology

Register now

Basic Immunology in Medicine: Update 2011
Wednesday, June 22, 2011, Marriott Wardman Park, Washington, DC

Course Description:
The purpose of the course is to review selected topics in basic immunology, with emphasis on recent advances and issues that are relevant to the pathogenesis and treatment of immune-mediated inflammatory diseases. This course was designed for practicing clinicians, trainees and individuals in biotechnology and pharmaceutical companies who are involved in the development of therapies for immunological diseases.

Learning Objectives:
At the conclusion of this course, attendees will be able to:

Course Faculty:
Abul Abbas, MD
Abul Abbas, MD
University of California — San Francisco
Andrew Lichtman, MD, PhD
Andrew Lichtman, MD, PhD
Brigham & Women's Hospital
Shiv Pillai, MD, PhD
Shiv Pillai, MD, PhD
Massachusetts General Hospital

View agenda.

$150: Course rate
$250: Package rate with Interventional Immunology

Register now

Interventional Immunology
Thursday, June 23, 2011, Marriott Wardman Park, Washington, DC

Course Description:
The Interventional Immunology course is intended to familiarize practicing physicians with the scientific basis of novel immune therapies, their clinical applications and possible side-effects and limitations.

Learning Objectives:
At the conclusion of this course, attendees will be able to:

Course Director:
Scott Plevy, MD
Scott Plevy, MD
University of North Carolina at Chapel Hill
View agenda.

$150: Course rate
$250: Package rate with Basic Immunology in Medicine: Update 2011
or Clinical Trials in Immunologic Disease

Register now

Translational Immunology Update
Are you Up to Date?
On September 15, 2010 FOCIS released the first issue of its electronic publication, Translational Immunology Update. The ePublication provides recent information from broad areas of translational immunology including highlights from recent literature, human immunophenotyping, basic immunology concepts, the underlying science of immune therapies and recent clinical trial results. While not exhaustive, each issue aggregates a wide range of information to provide a quick update without having to read every journal related to the field.

Translational Immunology Update was conceived by the Editorial Board comprised of Abul K. Abbas, MD, University of California-San Francisco; Carla J. Greenbaum, MD, Benaroya Research Institute; Andrew H. Lichtman, MD, PhD, Brigham & Women's Hospital; Holden T. Maecker, PhD, Stanford University and Scott E. Plevy, MD, University of North Carolina at Chapel Hill, who contribute to and author sections of each issue. Translational Immunology Update is delivered to your inbox every other month and is also available by visiting the FOCIS homepage. If you missed an issue, there is a previous issues link at the top of the most recent issue.

Member Society Spotlight: Americas Committee for Treatment and Research in Multiple Sclerosis (ACTRIMS)
Americas Committee for Treatment and Research in Multiple Sclerosis In 2010, the Americas Committee for Treatment and Research in Multiple Sclerosis (ACTRIMS) celebrated its 15th year as an organization. Established in 1995 and led by a steering committee of MS physicians and researchers from the US and Canada, ACTRIMS was incorporated in 2009 as a US-based non-profit, tax-exempt organization. ACTRIMS continues its long-standing collaborative partnership with National MS Society (USA) and the MS Society of Canada.

The purpose of ACTRIMS is to provide leadership in the field of multiple sclerosis and other demyelinating diseases. ACTRIMS is a community of MS-thought leaders dedicated to treatment and research in multiple sclerosis, dissemination of knowledge and education, collaboration among disciplines, and the development of the next generation of clinicians, clinical investigators and basic scientists in MS. It is presently a board-directed, non-membership organization.

ACTRIMS offers an annual education program on topics related to basic and clinical issues in MS research. Every three years, ACTRIMS and its European counterpart ECTRIMS offer a joint four-day annual program. In 2011, they will meet in Amsterdam and in 2014, in Boston. In alternate years, ACTRIMS offers a one-day meeting in collaboration with the Consortium of MS Centers at locations in the US or Canada. ACTRIMS also presents the annual Donald Paty Memorial Lecture. Instituted in 2005, the lecture provides an opportunity for ACTRIMS audiences to hear from a prestigious clinician or researcher selected for their knowledge, accomplishments and contributions related to multiple sclerosis.

What is on the horizon for ACTRIMS?
• 5th Joint Meeting of ECTRIMS and ACTRIMS, Amsterdam, the Netherlands, October 19-22, 2011

For more information about ACTRIMS, visit

ITN Announces New Opportunity for Clinical Investigators
Immune Tolerance Network The Immune Tolerance Network (ITN) is pleased to announce BioShare, a new Biomarker Sample Sharing opportunity from the Immune Tolerance Network. Interested investigators are invited to visit the Bioshare website, for information and access to clinical samples collected from ITN trials.

The ITN develops and conducts trials of novel immune tolerance therapies in type 1 diabetes and other autoimmune diseases, solid organ and islet transplantation, allergy and asthma. The ITN has stored hundreds of thousands of biospecimens from clinically well-phenotyped subjects that have participated in its trials, representing an important resource for future investigations. Samples collected from ITN trials that remain after performance of the protocol-specified assays are available for further studies through this BioShare website, the ITN's portal for sharing clinical samples with the scientific community.

To gain access to ITN samples, investigators from the scientific community are invited to submit research proposals through this website, anytime during the year. Proposals for use of ITN samples will undergo scientific review by the ITN. Please visit the website for more detailed information and proposal submission instructions.

FOCIS Centers of Excellence Spotlight: Institut Pasteur, Matthew Albert
Matthew Albert FOCIS: What is the coolest way that you facilitate interdisciplinary research?
Albert: The Centre d'Immunologie Humaine (CIH) is a collaborative research center with the stated mission to establish a translational research community around the shared desired to advance research on human immunology. We have identified several strategies to facilitate interdisciplinary research. First, we have an annual Journée de la Recherche Translationnelle (Translational Research Day). The goal of this symposium is to promote and nucleate a community for basic scientists interested in medically relevant research and clinicians committed to expanding our scientific knowledge of disease. In addition, we aim to encourage students and medical fellows to pursue a career in translational research. Since its creation, the symposium mixes talks from international leaders in the field of Translational Research and has provided a forum to present and discuss ongoing research projects in the CIH. This past year, we were able to raise money and support 10 travel awards for trainees within other European FCEs.

As a second strategy, the CIH has been organizing seminars and training on topics of interest for the members of the Centre and for the scientific community of the Institut Pasteur. To date, we have organized nine such seminars/training, primarily centered around key technologies present within the CIH-technology platform. This has stimulated several new collaborations between clinicians and scientists and provides a useful mechanism for identifying opportunities for interdisciplinary collaborations.

FOCIS: Why do you dig immunology?
Albert: We "dig" immunology because of its complexity and the fact that the study of immune responsiveness offers unique insight into our relationship with ourselves (e.g. questions of immunologic tolerance vs. autoimmunity/allergy) and our relationship with our environment (e.g. infectious disease). Claude Bernard, a French physiologist and the father of experimental medicine, coined the term Milieu Intérieur (or interior body fluids such as blood and plasma). He aimed to replace the ancient idea of "life forces" with a mechanistic process regulated through multiple equilibrium adjustment feedbacks (homeostasis). Following from recent breakthroughs, we as a community are now in a position to extend Bernard's concepts to establish determinants of immune homeostasis and immune response. Insightful analyses of these determinants will forge a direct path toward personalized medicine and will help revolutionize Western medicine.

FOCIS: What is your vision for the future of immunology?
Albert: Substantial progress in understanding the physiology of the immune system has been achieved in the last years. New immune pathways have been identified and the number of effector lymphocyte subsets have increased dramatically. This progress raises hopes that the immune system might be manipulated to control autoimmunity, tumor progression and vaccination. However, attempts to do so have been moderately successful and sometimes resulted in unexpected consequences. It appears evident that the immune system works in a more complex manner than previously anticipated and that the manipulation of single variants can result in dramatic systemic effects. Thus, the challenges ahead of us are great but the effort to understand and manipulate the immune system remains a high priority. High priority areas of research include: defining what is a healthy immune response; providing a systematic vie of the immune system; understanding the impact of the human microbiota on immune responsiveness; and development of innovative approaches for vaccination.

Events of Interest
Keystone Symposia: Dendritic Cells and the Initiation of Adaptive Immunity
February 12 - 17, 2011
Santa Fe, New Mexico, USA

Keystone Symposia: Cancer Control by Tumor Suppressors and Immune Effectors
February 12 - 17, 2011
Santa Fe, New Mexico, USA

Keystone Symposia: Mucosal Biology: A Fine Balance between Tolerance and Immunity
February 26 - March 3, 2011
Vancouver, British Columbia, Canada

Keystone Symposia: Immunity in the Respiratory Tract: Challenges of the Lung Environment
February 26 - March 3, 2011
Vancouver, British Columbia, Canada

Keystone Symposia: Immunologic Memory, Persisting Microbes and Chronic Disease
February 6 - 11, 2011
Banff, Alberta, Canada

Keystone Symposia: New Frontiers at the Interface of Immunity and Glycobiology
March 6 - 11, 2011
Lake Louise, Alberta, Canada

Clinical Research Single Topic Conference: Pediatric Liver Transplantation
March 18 - 19, 2011
Atlanta, Georgia, USA

Keystone Symposia: Immunoregulatory Networks
April 1 - 6, 2011
Breckenridge, Colorado, USA

Keystone Symposia: B Cells: New Insights into Normal versus Dysregulated Function
April 12 - 17, 2011
Whistler, British Columbia, Canada

The IL-1 Family of Cytokines: From Basic Biology to Clinical Applications
May 8 - 11, 2011
Clearwater, Florida, USA

3rd Annual International Certificate Program In Translational Medicine
May 8 - May 14, 2011
Siracusa, Italy

FOCIS Basic Immunology in Medicine: Update 2011
June 22, 2011
Washington, District of Columbia, USA

FOCIS Clinical Trials for Immunologic Disease
June 22, 2011
Washington, District of Columbia, USA

FOCIS Interventional Immunology Course
June 23, 2011
Washington, District of Columbia, USA

FOCIS 2011
June 23 - 26, 2011
Washington, District of Columbia, USA

15th International Congress of Mucosal Immunology
July 5 - 9, 2011
Paris, France

29th Annual Aspen Allergy Conference
July 26 - 30, 2011
Aspen, Colorado, USA

FOCIS 2012
June 20 - 23, 2012
Vancouver, British Columbia, Canada

FOCIS 2013
June 27 - 30, 2013
Boston, Massachusetts, USA

15th International Congress of Immunology
August 22 - 27, 2013
Rome, Italy

Grants Available
Remember to visit FOCIS Grants/Awards site regularly to view new grant opportunities in the field of clinical immunology and related disciplines. Grants are currently listed from the NIAID, NIDDK, NIAMS, NIH Roadmap and many more.

Career Opportunities: Here's What's Available Now
Juvenile Diabetes Research Foundation International (JDRF)
Scientific Program Manager, Immune Therapies

St. Jude Children's Research Hospital, Memphis TN
Associate Scientist

Post your career opportunities on the FOCIS website
Job posting rates:
$75 per posting — academic/non-profit/government
$125 per posting — industry

Job postings should be 250 words or less and will remain on the website for 90 days. To post your opportunities please email Amy Sahl.

FOCIS is a federation of societies that unite under the common mission to improve human health through immunology.

Academy of Clinical Laboratory Physicians and Scientists • American Academy of Allergy, Asthma and Immunology
American College of Rheumatology • American Rhinological Society • American Society for Blood and Marrow Transplantation
American Society for Histocompatibility and Immunogenetics • American Society of Nephrology • American Society of Transplantation
American Uveitis Society • Americas Committee for Treatment and Research in Multiple Sclerosis
Association of Medical Laboratory Immunologists • Australasian Society of Clinical Immunology and Allergy
British Society for Immunology • Center for International Blood and Marrow Transplant Research
Clinical Immunology Chapter of the Sociedad Mexicana de Immunología • Clinical Immunology Society
Commonwealth of Independent States Society of Allergology and Clinical Immunology
Croatian Society of Allergology and Clinical Immunology • Crohn's and Colitis Foundation of America
European Academy of Allergy & Clinical Immunology • European Society for Immunodeficiencies
European Society for Organ Transplantation • Georgian Association of Allegology and Clinical Immunology
German Society of Immunology • Immune Tolerance Network • Immunology of Diabetes Society
International Complement Society • International Cytokine Society • International Society for Interferon and Cytokine Research
International Society for NeuroImmunoModulation • International Society of Neuroimmunology
Israel Association of Allergy and Clinical Immunology • Italian Society of Allergology and Clinical Immunology
Japanese Society for Immunology • Lithuanian Society of Pulmonology and Allergy
National Institute of Allergy and Infectious Diseases • Pan American Group for Immunodefiency
Section of Clinical Immunology and Allergy of the Royal Society of Medicine
Section for Clinical Immunology of the Swedish Society of Medicine • Society of Innate Immunity • Society for Immunotheraphy of Cancer
Society for Investigative Dermatology • Society for Mucosal Immunology • The Transplantation Society
Ukrainian Society of Immunology and Allergy • Uveitis Association of Mexico • World Allergy Organization