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FOCIS 2011

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Program at a Glance

Sessions and speakers are preliminary and subject to change.

Wednesday, June 22
3:00-6:00 pm Registration Open
8:00 am-5:10 pm Basic Immunology in Medicine Course: Update 2011 (separate registration required)
8:30 am-5:00 pm Henry Kunkel Society's Annual Meeting (separate registration required)
8:30 am-5:00 pm Clinical Trials for Immunologic Disease Course (separate registration required)
Thursday, June 23
7:00 am-5:00 pm Registration Open
8:00 am-5:00 pm FOCIS Centers of Excellence Trainee Satellite Symposium (invitation only)
8:30 am-5:00 pm Henry Kunkel Society's Annual Meeting (separate registration required)
8:00 am-12:15 pm Tolerogenic B Cells and B Cell Signatures in Transplant Rejection and Tolerance
-Co-organized by the American Society of Transplantation (AST) and the American Society for Histocompatibility and Immunogenetics (ASHI)
8:00 am-12:15 pm Minimal Information About T Cell Assays (MIATA) Consensus Workshop
-Co-organized by the Association for Cancer Immunotherapy (CIMT) and the Cancer Immunotherapy Consortium of the Cancer Research Institute
8:30 am-5:00 pm Interventional Immunology Course (separate registration required)
9:00 am-5:00 pm Type 1 Diabetes - Insulitis Revisited:Cross-talk between the Immune System and the Beta Cell
-Co-organized by: Immunology of Diabetes Society (IDS) and the Juvenile Diabetes Research Foundation International (JDRF)
9:30 am-3:00 pm 58th International Union of Immunological Societies (IUIS) Council Meeting (invitation only)
Noon-6:15 pm Poster Session – Authors Optional
12:45-4:15 pm Recent Progress in Elucidating the Role of Host Genetics and Immune Responses in Transplantation and Infectious Disease: Implications for the Clinical Immunology/HLA Laboratory
-Co-organized by the Association of Medical  Laboratory Immunologists (AMLI) and the American Society for Histocompatibility and Immunogenetics (ASHI)
12:45-4:55 pm Follicle-like Structures in Target Organs of Autoimmune Disease:  A Mere Consequence, or Active Contributors to Tissue Injury?
-Co-organized by Americas Committee for Treatment and Research in Multiple Sclerosis (ACTRIMS) and the International Society for Neuroimmunology (ISNI)
12:45-5:00 pm Vaccination in the Context of Immunomodulatory Therapies
-Organized by the ILSI Health and Environmental Sciences Institute, Immunotoxicology Technical Committee (ITC)
5:30-6:30 pm Henry Kunkel Society Keynote Address: Adventures in Human Immunology (all delegates welcome)
-Mark Davis, PhD, Stanford University
6:30-8:30 pm Opening Reception with Exhibits & Poster Session with Authors Present
Friday, June 24
7:00 am-5:00 pm Registration Open
8:00 am-6:15 pm Poster Session – Authors Optional
8:00-9:45 am President's Symposium
-Immune Memory to Viral Infections, Rafi Ahmed, PhD, Emory University, School of Medicine
-The Struggle between Immunity and Pathogen in Tuberculosis, Stefan Kaufmann, PhD, Max-Planck-Institute
-From Babylon to Bethesda:  The Expanding Universe of Systemic Autoinflammatory Disease, Daniel Kastner, MD, PhD, NIH
10:00-11:45 am Plenary Session: T Cell Plasticity & Disease
-T Cell Plasticity & Disease, Jeffrey Bluestone, PhD, University of California-San Francisco
-Regulatory Immune Cell Subsets in the Immunological Disorders, Xuetao Cao, PhD, Chinese Academy of Medical Sciences
-Th17 Cells in Immunity and Autoimmunity, Federica Sallusto, PhD, Institute for Research in Biomedicine

Concurrent Thematic Symposia
Pathogenic Role of Antibodies
-The Elusive Roles of B Cell Responses in Multiple Sclerosis, Amit Bar-Or, MD, Montreal Neurological Institute, McGill University
-Abstract Presentation: The Marginal Zone B Cells Clonally Expanded in Hepatitis C-Related Mixed Cryoglobulinemia Display the Functional and Molecular Signatures of Anergy Induced by Continual B Cell Receptor Signaling, Marcella Visentini, MD, University La Sapienza of Rome
-Biological Function and Clinical Relevance of Antibodies to Transplantation Antigens, Elaine Reed, PhD, University of California – Los Angeles
-Abstract Presentation: Interleukin 6 Signaling Enhances Anti-aquaporin 4 Autoantibody Production from Plasmablasts in Neuromyelitis Optica, Norio Chihara, MD, National Institute of Neuroscience
-Dissecting the Human Antibody Response to Pathogens, Antonio Lanzavecchia, MD, Institute for Research in Biomedicine

-Transplantation Tolerance - Progress and Obstacles, Laurence Turka, MD, Beth Israel Deaconess Hospital
-Abstract Presentation: Changes in T Cell Subsets in 12 Patients Enrolled in a Tolerance Induction Protocol with Combined Kidney and Hematopoietic Cell Transplantation, Sussan Dejbakhsh-Jones, PhD, Stanford University
-The Allogeneic Response to Human Blood Vessels, Jordan Pober, MD, PhD, Yale University
-Abstract Presentation: Single-Cell Gene Profiling of Human Regulatory T Cell Subsets in Graft-Versus-Host Disease, Shen Dong, PhD, Institut Pasteur
-Targeting Memory in Transplantation, Allan Kirk, MD, PhD, NIH/NIDDK

Modeling Disease in Humanized Mice
-Modeling Disease in Humanized Mice, Richard Flavell, PhD, Yale University
-Abstract Presentation: A Novel NOD.SCID Mouse Model for Analysis of Growth and Therapy of CLL Supports an Important role for CD200 in Both, Karrie Wong, PhD, University of Toronto
-Reprogramming Tumor Immune Environment via Dendritic Cells, Carolina Palucka, MD, PhD, Baylor Institute of Biomedical Studies
-Abstract Presentation: Inhibition Of Cellular and Humoral Immune Resposes of Human Lymphocytes in vitro and in vivo by ILT3-Fc, George Vlad, PhD, Columbia University
-Humanized Mouse Models of Skin Inflammation, Frank Nestle, MD, King’s College London

3:00-5:00 pm Concurrent Oral Abstract Sessions
Regulatory Immune Cells
-Title TBA, Christopher E. Rudd, PhD, University of Cambridge
-Functional Human Regulatory T Cells Fail to Control Autoimmune Inflammation Due to Protein Kinase B/c-Akt Hyperactivation in Effector Cells, Ellen Wehrens, Wilhelmina Children’s Hospital, University Medical Center Utrecht
-Regulatory T Cells Control the Phenotype of Experimental Biliary Atresia by Dampening the Activation of Hepatic Dendritic Cells, Celine Silva Lages, PhD, Cincinnati Children's Hospital Medical Center
-BCL6 Controls the Th2 Inflammatory Activity of Regulatory T Cells, Deepali Sawant, PhD, Indiana University School of Medicine
-Naturally Occurring MHC Class I Restricted TCRs Effectively Redirect Human T Regulatory Cells to Suppress High Affinity, Polyfunctional CD8 T Cell Responses, James Riley, PhD, University of Pennsylvania
-Peripheral Insulin Recognition Dictates Pathogenic Versus Foxp3+ Regulatory CD4 T Cell Formation and Susceptibility to Type 1 Diabetes, Georgia Fousteri, PhD, La Jolla Institute for Allergy and Immunology
-Th1-like, IFN-gamma producing Tregs in Multiple Sclerosis, Margarita Dominguez-Villar, PhD, Yale University School of Medicine
-Human T Regulatory Cells Migrate to the Small Intestine and Produce IL-10 in Response to Teplizumab Therapy, Frank Waldron-Lynch, MD, PhD, Yale University School of Medicine
-Rapamycin Plus IL-2 Combination Therapy in T1D Subjects Enhances IL-2 Responsiveness in CD25+ Treg, but also NK and Effector T Cells, S. Alice Long, PhD, Benaroya Research Institute

Pathogens & Host Defense
-Tim3-Galectin 9 Interaction Controls Intracellular Mycobacterium Tuberculosis Replication, Isabel Sada-Ovalle, MD, PhD, National Institute of Respiratory Diseases
-Plexin-A4-Semaphorin 3A Signaling is Required for Toll-Like Receptor and Sepsis-Induced Cytokine Storm, Haitao Wen, PhD, University of North Carolina at Chapel Hill
-Cytosolic DNA-activated Human Dendritic Cells are Potent Activators of the Adaptive Immune Response, Katalin Kis-Toth, PhD, Beth Israel Deaconess Medical Center
-The miR-9/Blimp-1/IL-2 Axis Modulates the Balance between Activated and Regulatory T Cell Function and is Differentially Regulated in Progressive HIV Infection, Nabila Seddiki, PhD, University of New South Wales
-Oral Immunization with CVD 1256 Attenuated shigella dysenteriae 1 Results in Partial Protection Following Wild-Type Challenge in Cynomolgus Macaques, Franklin Toapanta, PhD, University of Maryland
-Essential Role for Methyl-CpG Binding Protein 2 (MeCP2) in Immune Regulation, Tianshu Yang, Baylor College of Medicine
-Mechanisms of Dectin-1 Dependent IL-17A Production during Invasive Fungal Infection, Jessica Werner, University of Alabama at Birmingham
3:00-5:00 pm Featured Course: Principles of Flow Cytometry for Immune Monitoring-Part I
-General Theories and Principles of Flow Cytometry, Stephen Perfetto, National Institutes of Health
-Instrument Setup, Quality Control and Standardization, Stephen Perfetto
-Compensation in Theory and in Practice, Stephen Perfetto
-Basic Panel Construction, Holden Maecker, PhD, Stanford University
-Staining Protocols and Considerations, Holden Maecker, PhD
5:15-6:15 pm Keynote Address: Genes, Mechanisms and Clinical Implications in Autoimmune Diabetes
-John Todd, PhD, University of Cambridge
6:15-7:30 pm Exhibits & Poster Session with Authors Present
Saturday, June 25
7:00 am-5:00 pm Registration Open
8:00 am-6:15 pm Poster Session – Authors Optional
8:00-9:45 am Plenary Session: Vaccine Development
-Targeting Dendritic Cells with Protein Vaccines and TLR Adjuvants Elicits Protective Multi-functional T Cell Immunity, Robert Seder, MD, National Institutes of Health
-DNA Vaccines Against Exotic Viral Diseases, Jay Hooper, PhD, U.S. Army Medical Research Institute of Infectious Diseases
-Integration and Innovation of Immunology and Vaccinology to Achieve a Decade of Vaccines, Chris Wilson, MD, Bill & Melinda Gates Foundation
10:00-11:45 am Plenary Session: Cancer Immunology and Immunotherapy 
-Cancer Therapy via Manipulation of T Cell Regulatory Pathways, Drew Pardoll, MD, PhD, John Hopkins University
-Cancer Immunotherapy Trials Network, Martin Cheever, MD, Seattle Cancer Care Alliance
-Cancer Immunoediting, Robert Schreiber, PhD, Washington University
-Inflammation, the Seventh Hallmark of Cancer, Alberto Mantovani, MD, Istituto Clinico Humanitas
1:00-2:45 pm

Concurrent Thematic Symposia
Gut Immunology
-Immunomodulatory Functions of Commensal Bacteria, Ivaylo Ivanov, PhD, Columbia University
-Abstract Presentation: Expression of TNFAIP3 (A20) in Intestinal Epithelial Cells Promotes Barrier Function and Protects Against Experimental Colitis, James Lodolce, PhD, University of Chicago
-Epithelial MicroRNAs and Gut Mucosal Immunity, Eli Pikarsky, MD, PhD, Hebrew University of Jerusalem
-Abstract Presentation: Molecular Mimicry and Human Microbiota are Involved in the Initiation of Autoimmune Responses, Umesh Deshmukh, PhD, University of Virginia
-Refining Association Signals at GWAS Loci: Lessons, Judy Cho, MD, Yale University

Innate Immunity in Disease
-Innate Responses in Viral Diseases, Christine Biron, PhD, Brown University
-Abstract Presentation: IL-17 Producing Mast Cells Contribute to Synovial Inflammation in Non-Psoriatic and Psoriatic Spondyloarthritis, Nataliya Yeremeko, PhD, University of Amsterdam
-Innate Lymphoid Cells and Mucosal Defense, James Di Santo, MD, PhD, Institut Pasteur
-Abstract Presentation: Human Plasmacytoid Dendritic Cells Express Dectin-1 as an Immune Regulatory Receptor, HyeMee Joo, PhD, Baylor Institute for Immunology Research
-Innate and Adaptive Immunity Edited by Natural Killer Cells, Fu-Dong Shi, MD, PhD, St. Joseph's Hospital and Medical Center

Costimulatory Pathways Regulating Disease
-Role of PD-1: PD-1 Ligand Pathway in Regulating the Balance Between T Cell Activation & Tolerance, Arlene Sharpe, MD, PhD, Harvard University
-Abstract Presentation: Cytokine-Mediated Cellular Mechanism Regulates Programmed Death Ligand-1 in Pediatric Systemic Lupus Erythematosus, Jing-Ni Ou, PhD, Seattle Children's Research Institute
-The Role of CTLA-4 in Regulating T Cell Responses, David Sansom, PhD, University of Birmingham
-Abstract Presentation: Ox40 Activation Can Augment and Hamper the Anti-Viral Immune Response in a Chronic Virus Infection, Tobias Boettler, MD, La Jolla Institute for Allergy and Immunology
-The LIGHT-HVEM-BTLA CoRegulatory System, Carl Ware, PhD, Sanford Burnham Medical Research Institute

3:00-5:00 pm Concurrent Oral Abstract Sessions
Probing Human Disease
Programmed by FOCIS, supported by Clinical & Experimental Immunology
-Identification of a Novel Human Primary Immunodeficiency with T Cell Activation Defect, Feng-Yen Li, National Institute of Allergy and Infectious Diseases
-Using Phosphoflow Cytometry to Interrogate Signaling Networks and Predict Drug Responses in Normal Human Thymocytes and T Cell Acute Lymphoblastic Leukemia, Michelle Hermiston, MD, PhD, University of California-San Francisco
-Immuno-therapy with Monoclonal TCR Guided Targeting, Yi Li, PhD, Immunocore, Ltd.
-Structure-based Selection of Small Molecules to Alter Allele-specific MHC Class II Antigen Presentation, Aaron Michels, MD, University of Colorado-Denver
-A Single Amino Acid Exchange in BAFF-R Associated with Primary Antibody Deficiency Alters Receptor Complex Formation and Signal Transduction, Kathrin Pieper, University Medical Center Freiburg
-Phosphorylated p38 MAPK Expression by Blood Lymphocytes of Allergic Asthmatic Humans Correlates with their Serum IgE levels, and Phosphorylated ERK Correlates with IgG Inhibition of Phosphorylated p38 MAPK Expression by T Cells is Associated with Suppression of IgE Responses, Jonathan Silverberg, MD, PhD, State University of New York Downstate Medical Center
-Autoimmune Disease Risk Variant of IFIH1 is Associated with Increased IFN-alpha Signaling and Serologic Autoimmunity in Lupus Patients, Timothy Niewold, MD, University of Chicago
-Human MMR-Deficiencies are Associated to Differently Impaired Antibody Maturation, Anne Durandy, MD, PhD, Universite Rene Descartes

Cytokines in Action
-Thymic Stromal Lymphopoietin (TSLP)-mediated Dermal Inflammation Aggravates Experimental Asthma, Hongwei Han, MD, PhD, Benaroya Research Institute
-An Innate, Non-NK T Cell with Memory-like Phenotype Produces Large Amounts of IL-17 Independently of IL-6 and IL-21, Anna Hansen, PhD, National Eye Institute
-Mechanisms Underlying Anti-IL-7R-alpha mAb Therapy of Autoimmune Diabetes, Hans Dooms, PhD, University of California, San Francisco
-Opposing Regulation of the Il17 Locus through Direct, Reciprocal Actions of STAT3 and STAT5, Xiangping Yang, PhD, National Institutes of Health
-Hierarchical IL-5 Expression Defines a Phenotypically and Epigenetically Distinct Subset of Highly Differentiated Th2 Cells, Yuzhi Yin, MD, PhD, National Institutes of Health
-Innate Lymphoid Cells Preferentially Express IL-17A and IL-22 in the Absence of T-bet in Intestinal Inflammation, Nick Powell, MD, King's College London, Barts and The London School of Medicine and Dentistry
-Card11 in Non-Th2 Cells Regulates IL-2 Responsiveness by Committed Th2 Cells in vivo to Control their Differentiation to Regulatory IL-10+ Th2 Cells, Matthew Cook, MD, PhD, Australian National University, Canberra Hospital
3:00-5:00 pm Featured Course: Principles of Flow Cytometry for Immune Monitoring-Part II
-Data Analysis, Maurice O’Gorman, PhD, Northwestern University
-Gating and Statistical Approaches, Maurice O’Gorman, PhD
-Automated Data Analysis, J. Philip McCoy, PhD, National Institutes of Health
-Exporting to Databases, J. Philip McCoy, PhD
-Publishing Your Data – Dos and Don’ts, J. Philip McCoy, PhD
5:15-6:15 pm FOCIS Presidential Keynote Address: Reconsidering Microbial Immunology through the Lens of Mucosal Ecology
-Jonathan Braun, MD, PhD, University of California-Los Angeles
6:15-7:30 pm Poster Reception with Authors Present
Sunday, June 26
8:00-9:45 am Plenary Session: Immunodeficiency Diseases
-Newborn Screening for Severe Combined Immunodeficiency/T Cell Lymphopenia: The Wisconsin Experience (2008-2010), James Verbsky, MD, PhD, Medical College of Wisconsin
-Primary Immunodeficiencies, Alain Fischer, MD, Hopital Necker-Enfants Malades
-Immunodeficiency and Lessons Learned for Mucosal Immunity, Scott Snapper, MD, PhD, Harvard Medical School
10:00-11:45 am Plenary Session: The Immune System in Metabolic & Cardiovascular Disease
-Type 2 Diabetes as an Inflammatory Disease, Marc Donath, MD, University Hospital Basel
-Innate Immunity Regulates Fat Metabolism, Ajay Chawla, MD, Stanford University
-Natural Helper Cells and Th2-type Innate Immunity, Shigeo Koyasu, PhD, Keio University